Research

Under 2023 inleddes en mer omfattande och fokuserad forskning om jästens effekter vid Sapienza-universitetet i Rom. Denna forskning använder C. elegans som är en modellorganism (en rundmask)  som ofta används för att studera livslängd. Rejuve Biotech i USA genomförde också fotskning med vår jäst. Där använder man en in vivo-modell med Drosophila (bananflugor) för att ytterligare analysera jästens egenskaper.

We have identified six different hallmarks wherein our results have indicated effects:

• Anti-inflammatory – contributes to the normal function of the immune system.
• Neurotrophins – support the brain’s growth factors (BDNF & NGF).
• Autophagy – promotes the cells’ natural recycling process.
• Antioxidant effect – protects cells from oxidative stress.
• Sarcopenia & muscle maintenance – protects cells from oxidative stress.

Increased survival – extends lifespan in studies with model organisms

Anti-inflammaging: The function of the immune system changes with age, which can lead to low-grade chronic inflammation – a phenomenon known as inflammaging. AgeViva has been shown to help maintain normal immune system function, which is a key factor for long-term health.

Neurotrophins: Deteriorations in the synthesis and release of neurotrophins, such as brain-derived neurotrophic factor (BDNF) and neurogrowth factor (NGF), are present during ageing. These trophic factors are necessity for growth, plasticity and recoveryof cells and tissues, including muscles, vital organs and blood. AgeViva promotes the expression in vitro of BDNF and NGF.

Autophagy: An intrinsic mechanism of the body to remove all cell debris (organelles, proteins, and cell membranes) when the energy resources to maintain these are not available and to avoid the possibility of inflammatory reactions. The process of autophagy removes expired proteins and other detritus in cells and through a series of reactions to derive the ‘building-stones’ for synthesis/formation of new cells. The deterioration of autophagy through ageing renders cellular functions ineffective thereby withholding the production of necessary enzymes for the synthesis of component building materials may proceed. Among older adults, disturbances of autophagy are more common.. AgeViva was shown to promote autophagy, which is part of the normal functioning of the immune system.

Antioxidant: Reactive oxygen species (ROS) induce several damaging effects: damaging DNA, lipids and proteins, disturbing cellular signalling and homeostasis, inducing inflammation and cell death. When the ageing body becomes incapable of blocking the ROS inductions, or reparation of ROS-damage it reverts to a condition of oxidative stress. Antioxidant actions antagonise the toxicity within cell physiology associated with oxidative stress, which accelerates ageing. In three studies, AgeViva was shown to promote antioxidant action.

Maintenance of muscles: The roundworm, C. elegans, a free-living, transparent nematode about 1 mm in length that has a lifespan of 12-18 days is ideally suited for studying ageing. It has two basic muscular functions: pharyngeal contractions and locomotor capacity applicable for measuring muscle function. In well-replicated studies, it was observed AgeViva maintained normal muscle activityin both pharyngeal contractions and locomotor capacity, particularly the older animals.

Survival: C. elegans has become the ‘organism-of-choice’ for studying longevity. Due to their limited lifespan, they have utilised for studies of survival following administrations of health-giving agents. AgeViva in several studies involving 250 roundworms was shown to extend C. elegans’ survival by 31 %.